Battling a familiar face in Lance Lynn, the White Sox offense struck first. Gavin Sheets doubled to left field to score Nicky Lopez, then Eloy Jiménez hit a sacrifice fly to center field to score Tommy Pham and put the Sox up 2–0 in the top of the 1st.
Korey Lee would tack on one more in the top frame of the 4th, reaching on a fielding error by Cardinals second baseman, Nolan Gorman, allowing Andrew Benintendi to cross home. Sox led by 3.
With two runners on, Cardinals Brendan Donovan doubled down the first base line to score both Nolan Gorman and Michael Siani, cutting the Sox lead to 1.